I want to buy a headset with a 3.5 mm connection and I wanted to ask if that fits in my Medion Akoya MD99451.
Fits.
3.5mm is the standard for almost every device and for almost all headphones.
3.5mm should fit. However, the laptop has such a combo audio jack, 1 jack for in and out. Do you need to know whether you need to switch from In to Out or a 4-pin socket is like the smartphone.
When switching the headset is not there, then you need a USB audio adapter with 2 sockets. Eg https://www.amazon.de/...00IRVQ0F8/