Mouse clicks will not be accepted?

And although I have the problem for a few hours that my laptop does not accept my mouse clicks. I can move the mouse properly. Even clicking is a certain time, then I go, for example, from Chrome on the Dekstop and already I can't click on anything. Then nothing works. I can move the mouse but do nothing else with it.

Have restarted the laptop several times, only a few minutes after the same problem again.

It's also not the mouse, because the mouse pad is exactly the same.
Do you have a solution?

Time Windows reset?