If you upload mods from 5 GB or if you upload over 50 mods?
I currently have about 15 mods activated and it actually still works smoothly, only sometimes slight FPS problems.
My LIfebook or notebook has 8 GB of RAM and the main settings of Skyrim are all set to the lowest, otherwise it would crash in any case.
So I played Skyrim with 1500 mods and it ran smoothly. ^^
But you have to try how much you can do, every mod uses different resources.
Did you play on pc?
Yes of course
How much RAM did your PC have?
32gb.
Well, that's 4 times more RAM than mine. No wonder.
The original version of Skyrim runs on 32 bit, which means that the program can use a maximum of 4GB of RAM, no matter how much your PC has. And even this version can still be played perfectly with over 200 mods.
If your Skyrim crashes on high settings and with a few mods, it is due to everything, except the RAM.